Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.4
USERS' SCORE
Good
Based on 2 Reviews
8.3
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Turmeric ExtractCurcuma longa (Rhizome)(95% [475 mg] Total Curcuminoids)
500 mg
â€
Top Medical Research Studies
9
We explored how curcumin, a natural compound found in turmeric, might help protect the heart during episodes of myocardial ischemia/reperfusion (I/R) injury. In a comprehensive analysis of 37 animal studies, we looked at the effects of curcumin on heart damage caused by interrupted blood flow, which is a common issue during heart attacks.
Our findings showed that curcumin seemed to have a significant positive impact on reducing the size of heart damage, improving heart function, and lowering harmful enzymes and oxidative stress in the heart muscle. We noted that these effects were consistent across various animal models and dosages used in the studies we reviewed. However, we also discovered some indications of publication bias in the reporting of certain results, which is something to consider in interpreting the data.
While the evidence from animal studies is promising, we must be cautious. It's essential to validate these findings through research in larger animal models and, ultimately, in human clinical trials before we can confidently recommend curcumin as a treatment for heart attack injuries.
Our findings showed that curcumin seemed to have a significant positive impact on reducing the size of heart damage, improving heart function, and lowering harmful enzymes and oxidative stress in the heart muscle. We noted that these effects were consistent across various animal models and dosages used in the studies we reviewed. However, we also discovered some indications of publication bias in the reporting of certain results, which is something to consider in interpreting the data.
While the evidence from animal studies is promising, we must be cautious. It's essential to validate these findings through research in larger animal models and, ultimately, in human clinical trials before we can confidently recommend curcumin as a treatment for heart attack injuries.
Read More
9
We designed a study to understand how curcumin, a compound found in turmeric, helps protect heart tissue during an event known as myocardial ischaemia-reperfusion injury. This injury occurs when blood flow returns to the heart after a blockage, often leading to further damage.
Using a model that simulates this condition, we treated rats with curcumin and monitored their heart health through various tests. We looked at indicators such as electrocardiograms (ECGs) and levels of specific proteins in the blood that signal heart stress and damage.
The results were promising. Curcumin appeared to improve heart function and reduce heart tissue damage compared to untreated rats. It lowered harmful enzyme levels and increased protective markers in the heart, indicating a clear beneficial impact. The study suggests curcumin activates a specific signaling pathway that helps to minimize inflammation, cell death, and oxidative stress in heart tissues.
Overall, our findings highlight curcumin's potential as a protective agent in heart attack scenarios. This natural compound may offer an avenue for enhancing heart health and recovery post-injury, making it a noteworthy supplement in the fight against heart disease.
Using a model that simulates this condition, we treated rats with curcumin and monitored their heart health through various tests. We looked at indicators such as electrocardiograms (ECGs) and levels of specific proteins in the blood that signal heart stress and damage.
The results were promising. Curcumin appeared to improve heart function and reduce heart tissue damage compared to untreated rats. It lowered harmful enzyme levels and increased protective markers in the heart, indicating a clear beneficial impact. The study suggests curcumin activates a specific signaling pathway that helps to minimize inflammation, cell death, and oxidative stress in heart tissues.
Overall, our findings highlight curcumin's potential as a protective agent in heart attack scenarios. This natural compound may offer an avenue for enhancing heart health and recovery post-injury, making it a noteworthy supplement in the fight against heart disease.
Read More
9
We explored the effects of curcumin, a compound found in turmeric, on inflammation following a heart attack, known scientifically as myocardial infarction (MI). The research focused on how curcumin could influence macrophage polarization, a key process in the body’s inflammatory response post-MI.
In our study, we discovered that curcumin significantly reduced heart remodeling three months after a heart attack and lower inflammation levels during the crucial first week that followed. Notably, curcumin appeared to shift the balance of macrophages in the heart. We saw a decrease in M1 macrophages—those associated with promoting inflammation—while M2 macrophages, which help reduce inflammation, were more prevalent after curcumin treatment.
Our experiments also included lab-based tests where curcumin decreased markers for M1 macrophages and boosted those for M2 macrophages under inflammatory conditions. Importantly, we found that curcumin's ability to adjust macrophage types was partly linked to a pathway that includes AMPK, a key energy regulator in cells.
Overall, these results suggest that curcumin can play a valuable role in reducing inflammation after heart attacks by changing how different macrophages function in the heart. This offers a promising perspective on the therapeutic potential of curcumin in heart health.
In our study, we discovered that curcumin significantly reduced heart remodeling three months after a heart attack and lower inflammation levels during the crucial first week that followed. Notably, curcumin appeared to shift the balance of macrophages in the heart. We saw a decrease in M1 macrophages—those associated with promoting inflammation—while M2 macrophages, which help reduce inflammation, were more prevalent after curcumin treatment.
Our experiments also included lab-based tests where curcumin decreased markers for M1 macrophages and boosted those for M2 macrophages under inflammatory conditions. Importantly, we found that curcumin's ability to adjust macrophage types was partly linked to a pathway that includes AMPK, a key energy regulator in cells.
Overall, these results suggest that curcumin can play a valuable role in reducing inflammation after heart attacks by changing how different macrophages function in the heart. This offers a promising perspective on the therapeutic potential of curcumin in heart health.
Read More
Most Useful Reviews
9
Supports heart health
1 people found this helpful
This is an excellent product. I take this curcumin twice daily with meals. It’s great for heart health, reduces cholesterol, combats cancer cells, and is anti-inflammatory.
Read More
6
Maintaining heart health
5 people found this helpful
I have used this for inflammation maintenance. Although I don't have major joint problems, I am 39 and thought it would help with the aches in my life. I also wanted it for heart maintenance, having had high BP in the past. I noticed some difference but eventually switched to Life Extension Curcumin; however, I’m unsure of the distinction between the two.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.4
- All Researches
9
We explored how curcumin, a compound derived from turmeric, can help protect the heart after a heart attack. The study focused on the damage caused when blood supply returns to the heart, known as reperfusion injury.
Using various tests, we discovered that curcumin could significantly improve cell viability and reduce cell damage during this process. It appeared to lower levels of harmful compounds and increase protective enzymes that combat oxidative stress and inflammation.
Interestingly, curcumin pretreatment also reduced ferroptosis (a form of cell death) and apoptosis (programmed cell death) while enhancing autophagy, which helps clean out damaged cells. This means that curcumin supports the heart by helping it cope better with the damaging effects of reperfusion.
Overall, our findings suggest that boosting HES1 levels plays a crucial role in this protective effect, creating a multi-faceted defense against further injury in heart tissue after a heart attack.
Using various tests, we discovered that curcumin could significantly improve cell viability and reduce cell damage during this process. It appeared to lower levels of harmful compounds and increase protective enzymes that combat oxidative stress and inflammation.
Interestingly, curcumin pretreatment also reduced ferroptosis (a form of cell death) and apoptosis (programmed cell death) while enhancing autophagy, which helps clean out damaged cells. This means that curcumin supports the heart by helping it cope better with the damaging effects of reperfusion.
Overall, our findings suggest that boosting HES1 levels plays a crucial role in this protective effect, creating a multi-faceted defense against further injury in heart tissue after a heart attack.
Read More
9
We investigated how curcumin, a compound found in turmeric, could help in healing after a heart attack by working alongside bone marrow-derived stem cells. In our study, we divided sixty-five male rats into four groups. One group was a healthy control, while another had a heart attack induced by a chemical. The third group received only stem cell treatment, and the fourth group was treated with both curcumin and stem cells.
Over several days post-heart attack, we measured important markers in the blood like lactate dehydrogenase and cardiac troponin, as well as factors like vascular endothelial growth factor (VEGF), which play a role in new blood vessel formation. Encouragingly, we noted a significant increase in VEGF levels in the group treated with curcumin and stem cells, suggesting improved blood supply to the heart.
Additionally, histopathological exams revealed better heart structure and more new capillaries in the treatment groups compared to the untreated group. Our findings indicate that the combination of curcumin with stem cells can boost blood vessel growth in the heart after a heart attack, potentially aiding recovery.
Over several days post-heart attack, we measured important markers in the blood like lactate dehydrogenase and cardiac troponin, as well as factors like vascular endothelial growth factor (VEGF), which play a role in new blood vessel formation. Encouragingly, we noted a significant increase in VEGF levels in the group treated with curcumin and stem cells, suggesting improved blood supply to the heart.
Additionally, histopathological exams revealed better heart structure and more new capillaries in the treatment groups compared to the untreated group. Our findings indicate that the combination of curcumin with stem cells can boost blood vessel growth in the heart after a heart attack, potentially aiding recovery.
Read More
9
We explored how curcumin, a compound found in turmeric, can help in treating heart attacks. The study introduced a two-step exosome delivery system designed to enhance the effectiveness of curcumin by targeting the heart directly while minimizing interactions with other organs, like the liver and spleen.
When curcumin is delivered using this smart exosome approach, it effectively reduces harmful substances like reactive oxygen species in damaged heart tissue. We observed improvements in various serum biomarkers, such as lactate dehydrogenase and malonyldialdehyde, suggesting that this method has better antioxidant capabilities compared to standard curcumin treatment.
Overall, this strategy enhances the therapeutic impact of curcumin and shows potential for use alone or alongside other treatments. Importantly, it achieves these benefits without causing harm to the rest of the body, which sets it apart from previous therapies that often had significant side effects.
When curcumin is delivered using this smart exosome approach, it effectively reduces harmful substances like reactive oxygen species in damaged heart tissue. We observed improvements in various serum biomarkers, such as lactate dehydrogenase and malonyldialdehyde, suggesting that this method has better antioxidant capabilities compared to standard curcumin treatment.
Overall, this strategy enhances the therapeutic impact of curcumin and shows potential for use alone or alongside other treatments. Importantly, it achieves these benefits without causing harm to the rest of the body, which sets it apart from previous therapies that often had significant side effects.
Read More
9
We explored how curcumin, a natural compound found in turmeric, might help protect the heart during episodes of myocardial ischemia/reperfusion (I/R) injury. In a comprehensive analysis of 37 animal studies, we looked at the effects of curcumin on heart damage caused by interrupted blood flow, which is a common issue during heart attacks.
Our findings showed that curcumin seemed to have a significant positive impact on reducing the size of heart damage, improving heart function, and lowering harmful enzymes and oxidative stress in the heart muscle. We noted that these effects were consistent across various animal models and dosages used in the studies we reviewed. However, we also discovered some indications of publication bias in the reporting of certain results, which is something to consider in interpreting the data.
While the evidence from animal studies is promising, we must be cautious. It's essential to validate these findings through research in larger animal models and, ultimately, in human clinical trials before we can confidently recommend curcumin as a treatment for heart attack injuries.
Our findings showed that curcumin seemed to have a significant positive impact on reducing the size of heart damage, improving heart function, and lowering harmful enzymes and oxidative stress in the heart muscle. We noted that these effects were consistent across various animal models and dosages used in the studies we reviewed. However, we also discovered some indications of publication bias in the reporting of certain results, which is something to consider in interpreting the data.
While the evidence from animal studies is promising, we must be cautious. It's essential to validate these findings through research in larger animal models and, ultimately, in human clinical trials before we can confidently recommend curcumin as a treatment for heart attack injuries.
Read More
9
We explored how curcumin, the key component in turmeric, affects heart health, particularly in the context of heart attacks due to myocardial ischemia-reperfusion injury. By examining both animal and human studies, we aimed to understand curcumin's cardioprotective properties.
Our analysis involved a review of 24 preclinical studies involving 503 animals and 4 clinical studies with 435 patients. These studies collectively pointed out that curcumin has significant benefits, reducing the size of heart injuries and improving cardiac function in animal models. Factors such as myocardial injury markers, oxidation, and inflammation all showed improvement with curcumin treatment.
In terms of clinical evidence, we found that curcumin could decrease the incidences of cardiac dysfunction and myocardial infarction during hospital stays, suggesting its potential due to anti-inflammatory and antioxidant properties. Interestingly, our research indicated an optimal dose of curcumin at 200 mg/kg/day, which is considered safe and non-toxic based on current literature.
Overall, this systematic review indicates that curcumin might be a valuable ally in protecting the heart, especially following events like a heart attack. However, we also noted that longer treatment durations and higher doses may be necessary for maximum efficacy in humans. Our findings propose important directions for further investigations into curcumin as a therapeutic option in heart health.
Our analysis involved a review of 24 preclinical studies involving 503 animals and 4 clinical studies with 435 patients. These studies collectively pointed out that curcumin has significant benefits, reducing the size of heart injuries and improving cardiac function in animal models. Factors such as myocardial injury markers, oxidation, and inflammation all showed improvement with curcumin treatment.
In terms of clinical evidence, we found that curcumin could decrease the incidences of cardiac dysfunction and myocardial infarction during hospital stays, suggesting its potential due to anti-inflammatory and antioxidant properties. Interestingly, our research indicated an optimal dose of curcumin at 200 mg/kg/day, which is considered safe and non-toxic based on current literature.
Overall, this systematic review indicates that curcumin might be a valuable ally in protecting the heart, especially following events like a heart attack. However, we also noted that longer treatment durations and higher doses may be necessary for maximum efficacy in humans. Our findings propose important directions for further investigations into curcumin as a therapeutic option in heart health.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
9
Supports heart health
1 people found this helpful
This is an excellent product. I take this curcumin twice daily with meals. It’s great for heart health, reduces cholesterol, combats cancer cells, and is anti-inflammatory.
Read More
6
Maintaining heart health
5 people found this helpful
I have used this for inflammation maintenance. Although I don't have major joint problems, I am 39 and thought it would help with the aches in my life. I also wanted it for heart maintenance, having had high BP in the past. I noticed some difference but eventually switched to Life Extension Curcumin; however, I’m unsure of the distinction between the two.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Yuan Y, Huang H, Hu T, Zou C, Qiao Y, et al. Curcumin pretreatment attenuates myocardial ischemia/reperfusion injury by inhibiting ferroptosis, autophagy and apoptosis via HES1. Int J Mol Med. 2024;54. doi:10.3892/ijmm.2024.5434
- Mirfakhraie N, Shoorei H, Abedpour N, Javanmard MZ. Co-treatment with bone marrow-derived mesenchymal stem cells and curcumin improved angiogenesis in myocardium in a rat model of MI. Mol Biol Rep. 2024;51:261. doi:10.1007/s11033-023-09180-z
- Chen M, Wang S, Chen Y, Shen H, Chen L, et al. Precision cardiac targeting: empowering curcumin therapy through smart exosome-mediated drug delivery in myocardial infarction. Regen Biomater. 2024;11:rbad108. doi:10.1093/rb/rbad108
- Liu W, Hu C, Long L, He S, Zhang W, et al. An injectable carrier for spatiotemporal and sequential release of therapeutic substances to treat myocardial infarction. J Control Release. 2024;365:29. doi:10.1016/j.jconrel.2023.10.056
- Zeng YF, Guo QH, Wei XY, Chen SY, Deng S, et al. Cardioprotective effect of curcumin on myocardial ischemia/reperfusion injury: a meta-analysis of preclinical animal studies. Front Pharmacol. 2023;14:1184292. doi:10.3389/fphar.2023.1184292
- Li T, Jin J, Pu F, Bai Y, Chen Y, et al. Cardioprotective effects of curcumin against myocardial I/R injury: A systematic review and meta-analysis of preclinical and clinical studies. Front Pharmacol. 2023;14:1111459. doi:10.3389/fphar.2023.1111459
- Hao H, Yuan T, Li Z, Zhang C, Liu J, et al. Curcumin analogue C66 ameliorates mouse cardiac dysfunction and structural disorders after acute myocardial infarction via suppressing JNK activation. Eur J Pharmacol. 2023;946:175629. doi:10.1016/j.ejphar.2023.175629
- Rostamzadeh F, Jafarinejad-Farsangi S, Ansari-Asl Z, Farrokhi MS, Jafari E. Treatment for Myocardial Infarction: In Vivo Evaluation of Curcumin-Loaded PEGylated-GQD Nanoparticles. J Cardiovasc Pharmacol. 2023;81:361. doi:10.1097/FJC.0000000000001410
- Pang BY, Wang YH, Ji XW, Leng Y, Deng HB, et al. Systematic review and meta-analysis of the intervention effect of curcumin on rodent models of myocardial infarction. Front Pharmacol. 2022;13:999386. doi:10.3389/fphar.2022.999386
- Hu C, Liu W, Long L, Wang Z, Zhang W, et al. Regeneration of infarcted hearts by myocardial infarction-responsive injectable hydrogels with combined anti-apoptosis, anti-inflammatory and pro-angiogenesis properties. Biomaterials. 2022;290:121849. doi:10.1016/j.biomaterials.2022.121849
- Pawar HD, Mahajan UB, Nakhate KT, Agrawal YO, Patil CR, et al. Curcumin Protects Diabetic Mice against Isoproterenol-Induced Myocardial Infarction by Modulating CB2 Cannabinoid Receptors. Life (Basel). 2022;12. doi:10.3390/life12050624
- Zhao J, Chen Y, Chen Q, Hong T, Zhong Z, et al. Curcumin Ameliorates Cardiac Fibrosis by Regulating Macrophage-Fibroblast Crosstalk IL18-P-SMAD2/3 Signaling Pathway Inhibition. Front Pharmacol. 2021;12:784041. doi:10.3389/fphar.2021.784041
- Tabaee S, Sahebkar A, Aghamohammadi T, Pakdel M, Dehabeh M, et al. The Effects of Curcumin Plus Piperine Supplementation in Patients with Acute Myocardial Infarction: A Randomized, Double-Blind, and Placebo-Controlled Trial. Adv Exp Med Biol. 2021;1328:199. doi:10.1007/978-3-030-73234-9_13
- Wu HJ, Zhang K, Ma JJ, Wang L, Zhuang Y. Mechanism of curcumin against myocardial ischaemia-reperfusion injury based on the P13K/Akt/mTOR signalling pathway. Eur Rev Med Pharmacol Sci. 2021;25:5490. doi:10.26355/eurrev_202109_26658
- Yan S, Zhou M, Zheng X, Xing Y, Dong J, et al. Anti-Inflammatory Effect of Curcumin on the Mouse Model of Myocardial Infarction through Regulating Macrophage Polarization. Mediators Inflamm. 2021;2021:9976912. doi:10.1155/2021/9976912
- Kang JY, Kim H, Mun D, Yun N, Joung B. Co-delivery of curcumin and miRNA-144-3p using heart-targeted extracellular vesicles enhances the therapeutic efficacy for myocardial infarction. J Control Release. 2021;331:62. doi:10.1016/j.jconrel.2021.01.018
